Article
A carboxyl-terminal determinant of the neuronal glutamate transporter, EAAC1, is required for platelet-derived growth factor-dependent trafficking.
The Journal of biological chemistry - 24 Feb 2006
Sheldon Amanda L, González Marco I, Robinson Michael B
Abstract excerpt
The neuronal glutamate transporter, EAAC1 (excitatory amino acid carrier 1), undergoes rapid regulation after treatment with platelet-derived growth factor (PDGF) or phorbol ester in C6 glioma cells and neurons. A large intracellular pool of EAAC1 exists, from which transporters are redistributed to the cell surface in response to these signals. Here we show that PDGF had no effect on subcellular localization of...
Topics
- Alanine
- Amino Acid Motifs
- Animals
- Biological Transport
- Biotinylation
- Blotting, Western
- Cell Line, Tumor
- Cell Membrane
- Cloning, Molecular
- DNA, Complementary
- Excitatory Amino Acid Transporter 2
- Excitatory Amino Acid Transporter 3
- Glutamic Acid