Article
Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1.
Neurochemistry international - 1 Jan 2000
O'Shea Ross D, Lau Chew L, Farso Mark C, Diwakarla Shanti, Zagami Chrissandra J, Svendsen Brian B, Feeney Sandra J, Callaway Jennifer K, Jones Nicole M, Pow David V, Danbolt Niels C, Jarrott Bevyn, Beart Philip M
Abstract excerpt
Excitatory amino acid transporters (EAATs) are responsible for homeostasis of extracellular L-glutamate, and the glial transporters are functionally dominant. EAAT expression or function is altered in acute and chronic neurological conditions, but little is known about the regulation of EAATs in reactive astroglia found in such neuropathologies. These studies examined the effects of the bacterial endotoxin...
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