Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants.

Cell - 19 Sept 2008

Dai Junbiao, Hyland Edel M, Yuan Daniel S, Huang Hailiang, Bader Joel S, Boeke Jef D

Abstract excerpt

Nucleosome structural integrity underlies the regulation of DNA metabolism and transcription. Using a synthetic approach, a versatile library of 486 systematic histone H3 and H4 substitution and deletion mutants that probes the contribution of each residue to nucleosome function was generated in Saccharomyces cerevisiae. We probed fitness contributions of each residue to perturbations of chromosome integrity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Fungal
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Library

Share to Gene Silencing

Share to Histones

Share to Nucleosomes

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18805098
DOI: 10.1016/j.cell.2008.07.019
PMCID: PMC2701395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants.PMID 18805098Read ↗

Nucleosome alterations caused by mutations at modifiable histone residues in Saccharomyces cerevisiae.Semantic proximity Read ↗

Population-scale chemical response revealed by a barcoded yeast collection.Semantic proximity Read ↗

HistoneHits: a database for histone mutations and their phenotypes.Semantic proximity Read ↗

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.Semantic proximity Read ↗

A robust toolkit for functional profiling of the yeast genome.Semantic proximity Read ↗

Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae.Semantic proximity Read ↗

Single residue changes to the histone core catalyze neofunctionalization and impose fitness trade-offsSemantic proximity Read ↗

Highly replicated experiments studying complex genotypes using nested DNA barcodesSemantic proximity Read ↗

Global analysis of functional surfaces of core histones with comprehensive point mutants.Semantic proximity Read ↗

Construction of Comprehensive Dosage-Matching Core Histone Mutant Libraries for Saccharomyces cerevisiae.Semantic proximity Read ↗

Design of synthetic yeast promoters via tuning of nucleosome architecture.Semantic proximity Read ↗

Barcode sequencing for understanding drug-gene interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.