Highly replicated experiments studying complex genotypes using nested DNA barcodes

Abstract excerpt

Many biological experiments involve studying the differences caused by genetic modifications, including genotypes composed of modifications at more than one locus. However, as the number and complexity of the genotypes increases, independently generating and tracking the necessary number of biological replicate samples becomes a major challenge. We developed a barcode-based method to track large numbers of indepen...

Topics

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• Aneuploidy
• DNA Barcoding, Taxonomic
• Gene Library
• Genotype
• High-Throughput Nucleotide Sequencing
• Oligonucleotide Array Sequence Analysis
• Plasmids
• Saccharomyces cerevisiae

Identifiers and source

Literature Corpus work

8d4b9ff7-ea87-5783-8b46-7d16972ea5cd

DOI

10.1101/2025.03.18.643964