Article
Prevalence of variations in melanoma susceptibility genes among Slovenian melanoma families.
BMC medical genetics - 19 Sept 2008
Peric Barbara, Cerkovnik Petra, Novakovic Srdjan, Zgajnar Janez, Besic Nikola, Hocevar Marko
Abstract excerpt
BACKGROUND: Two high-risk genes have been implicated in the development of CM (cutaneous melanoma). Germline mutations of the CDKN2A gene are found in < 25% of melanoma-prone families and there are only seven families with mutation of the CDK4 gene reported to date. Beside those high penetrance genes, certain allelic variants of the MC1R gene modify the risk of developing the disease. THE AIMS OF OUR STUDY WERE:...
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