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Article

Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.

Journal of affective disorders - 15 Mar 2018

Koike Shinsuke, Gaysina Darya, Jones Peter B, Wong Andrew, Richards Marcus

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) polymorphisms play an essential role in dopamine availability in the brain. However, there has been no study investigating whether a functional four-SNP (rs6269-rs4633-rs4818-rs4680) haplotype is associated with affective symptoms over the life course. METHODS: We tested this using 2093 members of the Medical Research Council National Survey of Health and...

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Share to Polymorphism, Single Nucleotide
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Source

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Identifiers

PMID: 29331705
DOI: 10.1016/j.jad.2017.12.044
PMCID: PMC5814675

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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