Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension.

Human molecular genetics - 1 Aug 2006

Kane Garvan C, Behfar Atta, Dyer Roy B, O'Cochlain D Fearghas, Liu Xiao-Ke, Hodgson Denice M, Reyes Santiago, Miki Takashi, Seino Susumu, Terzic Andre

Abstract excerpt

Heart failure is a growing epidemic, with systemic hypertension a major risk factor for development of disease. However, the molecular determinants that prevent the transition from a state of hypertensive load to that of overt cardiac failure remain largely unknown. Here in experimental hypertens...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Calcium
Share to Calcium Channel Blockers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Hypertension

Share to Metabolic Diseases

Share to Potassium Channels, Inwardly Rectifying

Share to Ventricular Remodeling

Source

Identifiers

PMID: 16782803
DOI: 10.1093/hmg/ddl154

Genes

KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16782803-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension.PMID 16782803Read ↗

Cardiac KATP channels in health and disease.Semantic proximity Read ↗

Proteomic profiling of KATP channel-deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome.Semantic proximity Read ↗

KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.Semantic proximity Read ↗

Human KATP channelopathies: diseases of metabolic homeostasisSemantic proximity Read ↗

Exploring the Role of the SLC12A Cation-Coupled Chloride Cotransporters in the Cardiovascular SystemSemantic proximity Read ↗

Physiological and pathophysiological roles of ATP-sensitive K+ channels.Semantic proximity Read ↗

Muscle KATP channels: recent insights to energy sensing and myoprotection.Semantic proximity Read ↗

Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.Semantic proximity Read ↗

Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload.Semantic proximity Read ↗

KATP Channels in the Cardiovascular System.Semantic proximity Read ↗

Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.Semantic proximity Read ↗

K<sub>ATP</sub>Channels and Cardiovascular DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.