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Article

Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy.

Gastroenterology - 1 Aug 2007

Van Mil Saskia W C, Milona Alexandra, Dixon Peter H, Mullenbach Roman, Geenes Victoria L, Chambers Jenny, Shevchuk Vasylyna, Moore Gudrun E, Lammert Frank, Glantz Anna G, Mattsson Lars-Ake, Whittaker John, Parker Malcolm G, White Roger, Williamson Catherine

Abstract excerpt

BACKGROUND AND AIMS: Intrahepatic cholestasis of pregnancy (ICP) is characterized by liver impairment, pruritus, and elevated maternal serum bile acids. It can cause premature delivery and intrauterine death. Bile acid synthesis, metabolism, and transport are regulated by the bile acid sensor FXR, and we hypothesized that genetic variation in FXR confers susceptibility to ICP. METHODS: The coding regions and...

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PMID: 17681172
DOI: 10.1053/j.gastro.2007.05.015

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