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Complex roles of cAMP–PKA–CREB signaling in cancer

24 Nov 2020

Abstract excerpt

Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes. cAMP can regulate the transcription of various target genes, mainly through protein kinase A (PKA) and its downstream effectors such as cAMP-responsive element binding protein (CREB). In addition, PKA can phosphorylate many...

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PMID: 33292604
DOI: 10.1186/s40164-020-00191-1

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