Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of cAMP, PKA and Rap1A in thyroid follicular cell survival.

Oncogene - 24 Jan 2002

Saavedra Arturo P, Tsygankova Oxana M, Prendergast Gregory V, Dworet Jessica H, Cheng Guanjun, Meinkoth Judy L

Abstract excerpt

Cyclic AMP (cAMP) rescues cells from apoptosis stimulated by diverse insults. We examined the role of cAMP as a survival factor, and the signaling pathways through which cAMP affords protection. Rat thyroid cells were selected for these studies given the predominant role of cAMP in thyrotropin (TSH)-stimulated proliferation and as an oncogene in thyroid cells. Wistar rat thyroid (WRT) cells perished via apoptosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP-Dependent Protein Kinases
Share to DNA Fragmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nitric Oxide Donors

Share to Nitroprusside

Share to rap1 GTP-Binding Proteins

Share to Ribosomal Protein S6 Kinases

Share to Thyroid Gland

Share to Thyrotropin

Source

Identifiers

PMID: 11850806
DOI: 10.1038/sj.onc.1205123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of cAMP, PKA and Rap1A in thyroid follicular cell survival.PMID 11850806Read ↗

Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.Semantic proximity Read ↗

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.Semantic proximity Read ↗

TGF-beta-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation.Semantic proximity Read ↗

Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.Semantic proximity Read ↗

The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals.Semantic proximity Read ↗

Regulation of Thyroid Cell Proliferation by TSH and Other Factors: A Critical Evaluation of in Vitro ModelsSemantic proximity Read ↗

Activation of the cAMP cascade in thyroid autonomy.Semantic proximity Read ↗

cAMP-dependent oncogenic action of Rap1b in the thyroid gland.Semantic proximity Read ↗

Biological activity of activating thyrotrophin receptor mutants: modulation by iodide.Semantic proximity Read ↗

Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activitySemantic proximity Read ↗

Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation.Semantic proximity Read ↗

p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.