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Article

Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.

Molecular and cellular biology - 1 Mar 2001

Tsygankova O M, Saavedra A, Rebhun J F, Quilliam L A, Meinkoth J L

Abstract excerpt

Originally identified as an antagonist of Ras action, Rap1 exhibits many Ras-independent effects, including a role in signaling pathways initiated by cyclic AMP (cAMP). Since cAMP is a critical mediator of the effects of thyrotropin (TSH) on cell proliferation and differentiation, we examined the regulation of Rap1 by TSH in a continuous line of rat thyroid-like cells. Both cAMP and protein kinase A (PKA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11238928
DOI: 10.1128/MCB.21.6.1921-1929.2001
PMCID: PMC86776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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