Article
cAMP-dependent oncogenic action of Rap1b in the thyroid gland.
The Journal of biological chemistry - 5 Nov 2004
Ribeiro-Neto Fernando, Leon Angelica, Urbani-Brocard Julie, Lou Liguang, Nyska Abraham, Altschuler Daniel L
Abstract excerpt
cAMP signaling leads to activation and phosphorylation of Rap1b. Using cellular models where cAMP stimulates cell proliferation, we have demonstrated that cAMP-mediated activation, as well as phosphorylation of Rap1b, is critical for cAMP stimulation of DNA synthesis. To determine whether Rap1b stimulates mitogenesis in vivo, we have constructed a transgenic mouse where a constitutively active G12V-Rap1b, flanked...
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