Identification of an invasion and tumor‐suppressing gene, <i>Endoglin</i> (<i>ENG</i>), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma

Abstract excerpt

Endoglin (ENG) has been identified as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma (ESCC). Earlier microcell-mediated chromosome transfer (MMCT) studies of chromosome 9 in ESCC narrowed down a tumor-suppressive critical region to 9q33-34. ENG maps to 9q34-qter and encodes a transformation growth factor beta (TGFbeta) superfamily auxiliary receptor. This study aims to identify the...

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