Applying polynomial standard curve method to correct bias encountered in estimating allele frequencies using DNA pooling strategy.

Abstract excerpt

DNA pooling approach is a cost-saving strategy which is crucial for multiple-SNP association study and particularly for laboratories with limited budget. However, the biased allele frequency estimates cannot be completely abolished by kappa correction. Using the SNaPshottrade mark, we systematically examined the relations between actual minor allele frequencies (AMiAFs) levels and estimates obtained from the...

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