Article
New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification.
Genetics - 1 Jan 2005
Yang Hsin-Chou, Pan Chia-Ching, Lu Richard C Y, Fann Cathy S J
Abstract excerpt
In the post-genome era, disease gene mapping using dense genetic markers has become an important tool for dissecting complex inheritable diseases. Locating disease susceptibility genes using DNA-pooling experiments is a potentially economical alternative to those involving individual genotyping. The foundation of a successful DNA-pooling association test is a precise and accurate estimation of allele frequency....
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