Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis

Abstract excerpt

Background & Aims Mutations in the trypsinogen gene ( PRSS1 ) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied the effects of expressing mutant forms of human PRSS1 in mice. Methods We expressed forms of PRSS1 with and without the mutation encoding R122H (PRSS1 R122H ) specifically in pancreatic acinar cells under control of a...

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