Article
The histopathology of SPINK1-associated chronic pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Dec 2020
Jones Terrell E, Bellin Melena D, Yadav Dhiraj, Freeman Martin L, Schwarzenberg Sarah J, Slivka Adam, Chennat Jennifer S, Beilman Gregory J, Chinnakotla Srinath, Pruett Timothy L, Kirchner Varvara, Humar Abhinav, Wijkstrom Martin, Zureikat Amer H, Nikiforova Marina N, Wald Abigail I, Whitcomb David C, Singhi Aatur D
Abstract excerpt
BACKGROUND: The identification of genetic risk factors for chronic pancreatitis, such as PRSS1, CFTR and SPINK1, provides the opportunity to define key pathologic hallmarks and etiologic-specific changes. For example, pancreata from PRSS1 and CFTR patients exhibit progressive lipomatous atrophy without significant fibrosis. Considering the pathology of SPINK1-associated pancreatitis is ill-defined, we examined...
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