Article
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Dec 2022
Fjeld Karianne, Gravdal Anny, Brekke Ranveig S, Alam Jahedul, Wilhelm Steven J, El Jellas Khadija, Pettersen Helene N, Lin Jianguo, Solheim Marie H, Steine Solrun J, Johansson Bente B, Njølstad Pål R, Verbeke Caroline S, Xiao Xunjun, Lowe Mark E, Molven Anders
Abstract excerpt
BACKGROUND & AIMS: The CEL gene encodes the digestive enzyme carboxyl ester lipase. CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant suggested to increase the risk of chronic pancreatitis (CP). Our aim was to develop a mouse model for CEL-HYB1 that enables studies of pancreatic disease mechanisms. METHODS: We established a knock-in mouse strain where the variable number of...
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