Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Abstract excerpt

Figure 2. Transgenic expression of human PRSS1 R122H caused severe AP. (A) Schema of cerulein-induced AP protocol. (B) Representative photos of pancreata from transgenic human PRSS1 R122H mice and C57BL/6J mice 24 hours after cerulein induction (n = 8). (C) Significant increase in pancreatic edema (pancreas-to-body weight ratio) in PRSS1 R122H mice 24 hours after cerulein induction. Mean SEM (n = 8). *P < 0.05;...

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