Article
Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.
Gastroenterology - 1 Jan 2013
Neuhöfer Patrick, Liang Song, Einwächter Henrik, Schwerdtfeger Christiane, Wartmann Thomas, Treiber Matthias, Zhang Hong, Schulz Hans-Ulrich, Dlubatz Karen, Lesina Marina, Diakopoulos Kalliope N, Wörmann Sonja, Halangk Walter, Witt Heiko, Schmid Roland M, Algül Hana
Abstract excerpt
BACKGROUND & AIMS: The transcription factor nuclear factor-κB (NF-κB) (a heterodimer of NF-κB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). However, it is not clear whether NF-κB promotes or protects against AP. We used the NF-κB inhibitor protein, inhibitor of κB (IκB)α, to study the roles of NF-κB in the development of AP in mice. METHODS: IκBα or the combination of IκBα and RelA selectively...
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