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Article

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.

Gastroenterology - 1 Dec 2006

Archer Herbert, Jura Natalia, Keller James, Jacobson Matthew, Bar-Sagi Dafna

Abstract excerpt

BACKGROUND & AIMS: Missense mutations in human cationic trypsinogen PRSS1 are frequently detected in patients with hereditary pancreatitis, a rare genetic disease of the pancreas characterized by autodigestive necrosis, chronic inflammation, and fibrosis. To examine the link between PRSS1 mutations and the initiation and progression of hereditary pancreatitis, we have sought to generate a transgenic mouse that...

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Source

Identifiers

PMID: 17087933
DOI: 10.1053/j.gastro.2006.09.049

Genes

PRSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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