Article
The histopathology of PRSS1 hereditary pancreatitis.
The American journal of surgical pathology - 1 Mar 2014
Singhi Aatur D, Pai Reetesh K, Kant Jeffrey A, Bartholow Tanner L, Zeh Herbert J, Lee Kenneth K, Wijkstrom Martin, Yadav Dhiraj, Bottino Rita, Brand Randall E, Chennat Jennifer S, Lowe Mark E, Papachristou Georgios I, Slivka Adam, Whitcomb David C, Humar Abhinav
Abstract excerpt
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred to as serine protease 1 (PRSS1). Other than inheritance, PRSS1 pancreatitis has been considered clinically and pathologically indistinguishable from other etiologies of chronic pancreatitis. However, to...
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