Article
Parallel mapping of genotypes to phenotypes contributing to overall biological fitness.
Metabolic engineering - 1 Nov 2008
Gall S, Lynch M D, Sandoval N R, Gill R T
Abstract excerpt
Laboratory selection is a powerful approach for engineering new traits in metabolic engineering applications. This approach is limited because determining the genetic basis of improved strains can be difficult using conventional methods. We have recently reported a new method that enables the measurement of fitness for all clones contained within comprehensive genomic libraries, thus enabling the genome-scale...
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