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Article

Genome-scale analysis of anti-metabolite directed strain engineering.

Metabolic engineering - 1 Mar 2008

Bonomo Jeanne, Lynch Michael D, Warnecke Tanya, Price James V, Gill Ryan T

Abstract excerpt

Classic strain engineering methods have previously been limited by the low-throughput of conventional sequencing technology. Here, we applied a new genomics technology, scalar analysis of library enrichments (SCALEs), to measure >3 million Escherichia coli genomic library clone enrichment patterns resulting from growth selections employing three aspartic-acid anti-metabolites. Our objective was to assess the...

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PMID: 18093856
DOI: 10.1016/j.ymben.2007.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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