Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SCALEs: multiscale analysis of library enrichment.

Nature methods - 1 Jan 2007

Lynch Michael D, Warnecke Tanya, Gill Ryan T

Abstract excerpt

We report a genome-wide, multiscale approach to simultaneously measure the effect that the increased copy of each gene and/or operon has on a desired trait or phenotype. The method involves (i) growth selections on a mixture of several different plasmid-based genomic libraries of defined insert sizes or SCALEs, (ii) microarray studies of enriched plasmid DNA, and a (iii) mathematical multiscale analysis that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Directed Molecular Evolution
Share to DNA, Bacterial
Share to DNA Fragmentation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genomic Library

Share to Oligonucleotide Array Sequence Analysis

Share to Open Reading Frames

Share to Plasmids

Source

Identifiers

PMID: 17099705
DOI: 10.1038/nmeth946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SCALEs: multiscale analysis of library enrichment.PMID 17099705Read ↗

Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes.Semantic proximity Read ↗

Parallel mapping of genotypes to phenotypes contributing to overall biological fitness.Semantic proximity Read ↗

ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth.Semantic proximity Read ↗

Selection analyses of insertional mutants using subgenic-resolution arrays.Semantic proximity Read ↗

Multiplexed tracking of combinatorial genomic mutations in engineered cell populations.Semantic proximity Read ↗

Genome-scale analysis of anti-metabolite directed strain engineering.Semantic proximity Read ↗

One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY!Semantic proximity Read ↗

An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli.Semantic proximity Read ↗

Development of ultra-high-density screening tools for microbial "omics".Semantic proximity Read ↗

Phenomic assessment of genetic buffering by kinetic analysis of cell arrays.Semantic proximity Read ↗

From genes to genomes: universal scale-invariant properties of microbial chromosome organisation.Semantic proximity Read ↗

Pleiotropic hubs drive bacterial surface competition through parallel changes in colony composition and expansion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.