Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus.

The Journal of rheumatology - 1 Nov 2008

Summers Carolyn M, Cucchiara Andrew J, Nackos Eleni, Hammons Andrea L, Mohr Elisabeth, Whitehead Alexander S, Von Feldt Joan M

Abstract excerpt

OBJECTIVE: To determine if functional polymorphisms of folate/homocysteine pathway enzymes are associated with homocysteine concentrations and/or coronary artery calcification (CAC) scores in patients with systemic lupus erythematosus (SLE) and controls. METHODS: We investigated 163 SLE patients and 160 controls. Functional polymorphisms in 6 genes in the folate/homocysteine pathway were genotyped:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Asian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystathionine beta-Synthase

Share to Enzymes

Share to Ferredoxin-NADP Reductase

Share to Hispanic or Latino

Share to Tetrahydrofolate Dehydrogenase

Share to Thymidylate Synthase

Source

Open in PubMed Open full text

Identifiers

PMID: 18785313
DOI: 10.3899/jrheum.080071
PMCID: PMC4030675

Genes

MTHFR
CBS
DHFR
MTR
MTRR
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus.PMID 18785313Read ↗

Contribution of MTHFR gene variants in lupus related subclinical atherosclerosis.Semantic proximity Read ↗

Homocysteine, methylenetetrahydrofolate reductase polymorphism, antiphospholipid antibodies, and thromboembolic events in systemic lupus erythematosus: a retrospective cohort study.Semantic proximity Read ↗

Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study.Semantic proximity Read ↗

No evidence for hyperhomocysteinemia or increased prevalence of genetic polymorphisms in the homocysteine pathway in patients with moderate juvenile idiopathic arthritis.Semantic proximity Read ↗

Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank.Semantic proximity Read ↗

Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.Semantic proximity Read ↗

Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis.Semantic proximity Read ↗

Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.Semantic proximity Read ↗

Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexateSemantic proximity Read ↗

Determinants of homocysteine levels in colorectal and breast cancer patients.Semantic proximity Read ↗

Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.