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Article

Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis.

Gene - 30 Dec 2017

Salimi Saeedeh, Keshavarzi Farshid, Mohammadpour-Gharehbagh Abbas, Moodi Mahdieh, Mousavi Mahdieh, Karimian Mohammad, Sandoughi Mahnaz

Abstract excerpt

Systemic lupus erythematosus (SLE) is a typical autoimmune disorder with multiple organ involvement and unknown etiology. It has been shown that polymorphic variants of the genes encoding key enzymes of folate and methionine metabolism may influence DNA methylation. Genomic DNA was extracted from blood samples of 150 SLE patients and 160 controls, matching age, sex, and ethnicity. MTHFR rs1801133C>T and MTR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28943344
DOI: 10.1016/j.gene.2017.09.037

Genes

MTHFR
DHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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