Article
Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity.
Arthritis research & therapy - 1 Jan 2008
Wither Joan, Cai Yong-chun, Lim Sooyeol, McKenzie Tamara, Roslin Nicole, Claudio Jaime O, Cooper Glinda S, Hudson Thomas J, Paterson Andrew D, Greenwood Celia M T, Gladman Dafna, Pope Janet, Pineau Christian A, Smith C Douglas, Hanly John G, Peschken Christine, Boire Gilles, Fortin Paul R
Abstract excerpt
INTRODUCTION: Systemic lupus erythematosus is a genetically complex disease. Currently, the precise allelic polymorphisms associated with this condition remain largely unidentified. In part this reflects the fact that multiple genes, each having a relatively minor effect, act in concert to produce disease. Given this complexity, analysis of subclinical phenotypes may aid in the identification of susceptibility...
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