Article
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Jan 2005
Blanco Patrick, Pitard Vincent, Viallard Jean-François, Taupin Jean-Luc, Pellegrin Jean-Luc, Moreau Jean-François
Abstract excerpt
OBJECTIVE: Cytotoxic T lymphocyte-mediated killing using granzyme B has recently been proposed to be a preferential and selective source of autoantigens in systemic autoimmune diseases, including systemic lupus erythematosus (SLE), while other reports have indicated that cytolytic activity in SLE patients was decreased. The aim of this study was to examine the phenotypic and functional status of the CD8+ T cells...
Topics
- Adolescent
- Adult
- Aged
- Autoantibodies
- Autoantigens
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Dendritic Cells
- Female
- Granzymes
- Humans
- Lupus Erythematosus, Systemic
- Lymphocyte Activation