Article
Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension.
Circulation - 28 Aug 2012
Ormiston Mark L, Chang Chiwen, Long Lu L, Soon Elaine, Jones Des, Machado Rajiv, Treacy Carmen, Toshner Mark R, Campbell Kate, Riding Alex, Southwood Mark, Pepke-Zaba Joanna, Exley Andrew, Trembath Richard C, Colucci Francesco, Wills Mark, Trowsdale John, Morrell Nicholas W
Abstract excerpt
BACKGROUND: Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary arterial hypertension (PAH) is characterized by severe pulmonary vascular remodeling and has long been associated with immune dysfunction. Despite this association, a role for NK cells in disease pathology has not yet been described. METHODS...
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