Article
Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women.
Journal of medical genetics - 1 Jan 2009
Chan K Y-K, Liu W, Long J-R, Yip S-P, Chan S-Y, Shu X-O, Chua D T-T, Cheung A N-Y, Ching J C-Y, Cai H, Au G K-H, Chan M, Foo W, Ngan H Y-S, Gao Y-T, Ngan E S-W, Garcia-Barceló M-M, Zheng Wei, Khoo U-S
Abstract excerpt
BACKGROUND: The BRCA1 gene is an important breast-cancer susceptibility gene. Promoter polymorphisms can alter the binding affinity of transcription factors, changing transcriptional activity and may affect susceptibility to disease. METHODS AND RESULTS: Using direct sequencing of the BRCA1 promoter region, we identified four polymorphisms c.-2804T-->C (rs799908:T-->C), c.-2265C-->T (rs11655505:C-->T),...
Topics
- Asian People
- BRCA1 Protein
- Binding Sites
- Breast Neoplasms
- Case-Control Studies