Article
Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women.
Oncotarget - 1 Mar 2016
Ling Hong, Li Shan, Wu Yang, Zheng Yi-Zi, Qiao Feng, Yao Ling, Cao Zhi-Gang, Ye Fu-Gui, Wu Jiong, Hu Xin, Wang Bin, Shao Zhi-Ming
Abstract excerpt
BACKGROUND: The tumor suppressor BRCA1 plays a pivotal role in maintaining genomic stability and tumor suppression. The BRCA1-A complex is required for recruitment of BRCA1 to DNA damage sites, DNA repair and cell cycle checkpoint control. Since germline mutations of BRCA1 often lead to breast tumors that are triple-negative breast cancer (TNBC) type, we aimed to investigate whether genetic deficiency in genes of...
Topics
- Adaptor Proteins, Signal Transducing
- Asian People
- BRCA1 Protein
- Carrier Proteins
- Case-Control Studies
- China
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Deubiquitinating Enzymes