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Article

Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling

10 Mar 2017

Abstract excerpt

Epstein-Barr virus-induced gene 3 (EBI3) is a subunit of the composite cytokines IL-27 and IL-35. Both have beneficial functions or effects in models of infectious and autoimmune diseases. This suggests that administration of EBI3 could be therapeutically useful by binding free p28 and p35 to generate IL-27 and IL-35. IL-27- and IL-35-independent functions of EBI3 could compromise its therapeutic uses. We...

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PMID: 28280243
DOI: 10.1074/jbc.m116.762021

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