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Article

Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008

Shaw A Joe, Podkaminer Kara K, Desai Sunil G, Bardsley John S, Rogers Stephen R, Thorne Philip G, Hogsett David A, Lynd Lee R

Abstract excerpt

We report engineering Thermoanaerobacterium saccharolyticum, a thermophilic anaerobic bacterium that ferments xylan and biomass-derived sugars, to produce ethanol at high yield. Knockout of genes involved in organic acid formation (acetate kinase, phosphate acetyltransferase, and L-lactate dehydrogenase) resulted in a strain able to produce ethanol as the only detectable organic product and substantial changes in...

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Identifiers

PMID: 18779592
DOI: 10.1073/pnas.0801266105
PMCID: PMC2544529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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