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Article

Transcriptomic and proteomic changes from medium supplementation and strain evolution in high-yielding Clostridium thermocellum strains.

Journal of industrial microbiology & biotechnology - 1 Nov 2018

Papanek Beth, O'Dell Kaela B, Manga Punita, Giannone Richard J, Klingeman Dawn M, Hettich Robert L, Brown Steven D, Guss Adam M

Abstract excerpt

Clostridium thermocellum is a potentially useful organism for the production of lignocellulosic biofuels because of its ability to directly deconstruct cellulose and convert it into ethanol. Previously engineered C. thermocellum strains have achieved higher yields and titers of ethanol. These strains often initially grow more poorly than the wild type. Adaptive laboratory evolution and medium supplementation have...

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PMID: 30187243
DOI: 10.1007/s10295-018-2073-x

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