Article
Construction and evolution of an Escherichia coli strain relying on nonoxidative glycolysis for sugar catabolism.
Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2018
Lin Paul P, Jaeger Alec J, Wu Tung-Yun, Xu Sharon C, Lee Abraxa S, Gao Fanke, Chen Po-Wei, Liao James C
Abstract excerpt
The Embden-Meyerhoff-Parnas (EMP) pathway, commonly known as glycolysis, represents the fundamental biochemical infrastructure for sugar catabolism in almost all organisms, as it provides key components for biosynthesis, energy metabolism, and global regulation. EMP-based metabolism synthesizes three-carbon (C3) metabolites before two-carbon (C2) metabolites and must emit one CO2 in the synthesis of the C2...
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