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Article

A functional metagenomic approach for expanding the synthetic biology toolbox for biomass conversion.

Molecular systems biology - 13 Apr 2010

Sommer Morten O A, Church George M, Dantas Gautam

Abstract excerpt

Sustainable biofuel alternatives to fossil fuel energy are hampered by recalcitrance and toxicity of biomass substrates to microbial biocatalysts. To address this issue, we present a culture-independent functional metagenomic platform for mining Nature's vast enzymatic reservoir and show its relevance to biomass conversion. We performed functional selections on 4.7 Gb of metagenomic fosmid libraries and show that...

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Identifiers

PMID: 20393580
DOI: 10.1038/msb.2010.16
PMCID: PMC2872612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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