Article
Elucidating central metabolic redox obstacles hindering ethanol production in Clostridium thermocellum.
Metabolic engineering - 1 Nov 2015
Thompson R Adam, Layton Donovan S, Guss Adam M, Olson Daniel G, Lynd Lee R, Trinh Cong T
Abstract excerpt
Clostridium thermocellum is an anaerobic, Gram-positive, thermophilic bacterium that has generated great interest due to its ability to ferment lignocellulosic biomass to ethanol. However, ethanol production is low due to the complex and poorly understood branched metabolism of C. thermocellum, and in some cases overflow metabolism as well. In this work, we developed a predictive stoichiometric metabolic model...
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