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Article

The role of AdhE mutations in Thermoanaerobacterium saccharolyticum.

Journal of bacteriology - 22 May 2025

Fabri João Henrique T M, Pech-Canul Angel, Ziegler Samantha J, Burgin Tucker Emme, Richardson Isaiah D, Maloney Marybeth I, Bomble Yannick J, Lynd Lee R, Olson Daniel G

Abstract excerpt

Thermoanaerobacterium saccharolyticum is a thermophilic anaerobic bacterium that natively ferments a variety of hemicellulose substrates to organic acids and alcohols. It has recently been engineered to produce ethanol at high yield and titer; however, it uses a unique metabolic pathway for ethanol production that is poorly characterized. One of the distinctive aspects of this pathway is the presence of...

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Topics

Thermoanaerobacterium
Ethanol
Alcohol Dehydrogenase
Bacterial Proteins
Mutation
Acetyl Coenzyme A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fermentation

Gene Expression Regulation, Bacterial

Source

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Identifiers

PMID: 40304514
DOI: 10.1128/jb.00015-25
PMCID: PMC12096837

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