Article
Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011
Brown Steven D, Guss Adam M, Karpinets Tatiana V, Parks Jerry M, Smolin Nikolai, Yang Shihui, Land Miriam L, Klingeman Dawn M, Bhandiwad Ashwini, Rodriguez Miguel, Raman Babu, Shao Xiongjun, Mielenz Jonathan R, Smith Jeremy C, Keller Martin, Lynd Lee R
Abstract excerpt
Clostridium thermocellum is a thermophilic, obligately anaerobic, gram-positive bacterium that is a candidate microorganism for converting cellulosic biomass into ethanol through consolidated bioprocessing. Ethanol intolerance is an important metric in terms of process economics, and tolerance has often been described as a complex and likely multigenic trait for which complex gene interactions come into play....
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