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Article

Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.

Biophysical journal - 1 May 2003

Takahashi Shoji X, Mittman Scott, Colecraft Henry M

Abstract excerpt

Sequence analysis of the human genome permitted cloning of five Ca(2+)-channel beta(2) splice variants (beta(2a)-beta(2e)) that differed only in their proximal amino-termini. The functional consequences of such beta(2)-subunit diversity were explored in recombinant L-type channels reconstituted in HEK 293 cells. Beta(2a) and beta(2e) targeted autonomously to the plasma membrane, whereas beta(2b)-beta(2d)...

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Identifiers

PMID: 12719232
DOI: 10.1016/S0006-3495(03)70027-7
PMCID: PMC1302863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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