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Article

Inactivation of L-type calcium channels is determined by the length of the N terminus of mutant beta(1) subunits.

Pflugers Archiv : European journal of physiology - 1 Feb 2010

Jangsangthong Wanchana, Kuzmenkina Elza, Khan Ismail F Y, Matthes Jan, Hullin Roger, Herzig Stefan

Abstract excerpt

Voltage-dependent calcium channel (Ca(v)) pores are modulated by cytosolic beta subunits. Four beta-subunit genes and their splice variants offer a wide structural array for tissue- or disease-specific biophysical gating phenotypes. For instance, the length of the N terminus of beta(2) subunits has major effects on activation and inactivation rates. We tested whether a similar mechanism principally operates in a...

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PMID: 19821165
DOI: 10.1007/s00424-009-0738-z

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Inactivation of L-type calcium channels is determined by the length of the N terminus of mutant beta(1) subunits.PMID 19821165Read ↗

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