Article
Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.
Molecular biology of the cell - 1 Apr 2014
Sun Yi, Chiu Tim T, Foley Kevin P, Bilan Philip J, Klip Amira
Abstract excerpt
Rab-GTPases are important molecular switches regulating intracellular vesicle traffic, and we recently showed that Rab8A and Rab13 are activated by insulin in muscle to mobilize GLUT4-containing vesicles to the muscle cell surface. Here we show that the unconventional motor protein myosin Va (MyoVa) is an effector of Rab8A in this process. In CHO-IR cell lysates, a glutathione S-transferase chimera of the...
Topics
- Animals
- Binding Sites
- Cell Line
- Cell Nucleus
- Exocytosis
- Gene Knockdown Techniques
- Gene Silencing
- Glucose Transporter Type 4
- Guanosine Triphosphate
- Humans
- Insulin