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Article

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation.

Neurogenetics - 1 Feb 2009

Skoglund Lena, Brundin RoseMarie, Olofsson Tommie, Kalimo Hannu, Ingvast Sofie, Blom Elin S, Giedraitis Vilmantas, Ingelsson Martin, Lannfelt Lars, Basun Hans, Glaser Anna

Abstract excerpt

Mutations in the progranulin (PGRN) gene have recently been identified in families with frontotemporal lobar degeneration and ubiquitin-positive brain inclusions linked to chromosome 17q21. We have previously described a Swedish family displaying frontotemporal dementia with rapid progression and linkage to chromosome 17q21. In this study, we performed an extended clinical and neuropathological investigation of...

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Identifiers

PMID: 18855025
DOI: 10.1007/s10048-008-0155-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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