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Article

Low serum progranulin predicts the presence of mutations: a prospective study.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Schofield Emma C, Halliday Glenda M, Kwok John, Loy Clement, Double Kay L, Hodges John R

Abstract excerpt

Serum progranulin is decreased in frontotemporal dementia (FTD) patients with progranulin gene (PGRN) mutations. We investigate the utility of prospective serum screening as a surrogate diagnostic marker for progranulin mutations. A commercial ELISA was used to measure progranulin protein concent...

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Identifiers

PMID: 20858962
DOI: 10.3233/JAD-2010-101032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20858962-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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