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Article

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

Liu Xinyu, Fortin Pascal D, Walsh Christopher T

Abstract excerpt

Andrimid is a hybrid nonribosomal peptide-polyketide antibiotic that blocks the carboxyl-transfer reaction of bacterial acetyl-CoA carboxylase (ACC) and thereby inhibits fatty acid biosynthesis with submicromolar potency. The andrimid biosynthetic gene cluster from Pantoea agglomerans encodes an admT gene with homology to the acetyl-CoA carboxyltransferase (CT) beta-subunit gene accD. Escherichia coli cells...

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Identifiers

PMID: 18768797
DOI: 10.1073/pnas.0806873105
PMCID: PMC2533188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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