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The Carboxyltransferase Activity of the Apicoplast Acetyl-CoA Carboxylase of Toxoplasma gondii Is the Target of Aryloxyphenoxypropionate Inhibitors

1 Jun 2002

Abstract excerpt

Inhibition of growth of the apicomplexan parasite Toxoplasma gondii by aryloxyphenoxypropionate herbicides has been correlated with the inhibition of its acetyl-CoA carboxylase (ACC) by these compounds. Here, full-length and C-terminal fragments of T. gondii apicoplast ACC as well as C-terminal fragments of the cytosolic ACC were expressed in Escherichia coli. The recombinant proteins that were soluble showed the...

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PMID: 11980900
DOI: 10.1074/jbc.m200455200

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