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Article

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.

The Journal of biological chemistry - 18 Jun 2004

Freiberg Christoph, Brunner Nina A, Schiffer Guido, Lampe Thomas, Pohlmann Jens, Brands Michael, Raabe Martin, Häbich Dieter, Ziegelbauer Karl

Abstract excerpt

The multisubunit acetyl-CoA carboxylase, which catalyzes the first committed step in fatty acid biosynthesis, is broadly conserved among bacteria. Its rate-limiting role in formation of fatty acids makes this enzyme an attractive target for the design of novel broad-spectrum antibacterials. Howev...

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Identifiers

PMID: 15066985
DOI: 10.1074/jbc.M402989200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15066985-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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