Article
Screening of metagenomic and genomic libraries reveals three classes of bacterial enzymes that overcome the toxicity of acrylate.
PloS one - 1 Jan 2014
Curson Andrew R J, Burns Oliver J, Voget Sonja, Daniel Rolf, Todd Jonathan D, McInnis Kathryn, Wexler Margaret, Johnston Andrew W B
Abstract excerpt
Acrylate is produced in significant quantities through the microbial cleavage of the highly abundant marine osmoprotectant dimethylsulfoniopropionate, an important process in the marine sulfur cycle. Acrylate can inhibit bacterial growth, likely through its conversion to the highly toxic molecule acrylyl-CoA. Previous work identified an acrylyl-CoA reductase, encoded by the gene acuI, as being important for...
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