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Article

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.

Molecular biology of the cell - 1 Nov 2008

Sou Yu-shin, Waguri Satoshi, Iwata Jun-ichi, Ueno Takashi, Fujimura Tsutomu, Hara Taichi, Sawada Naoki, Yamada Akane, Mizushima Noboru, Uchiyama Yasuo, Kominami Eiki, Tanaka Keiji, Komatsu Masaaki

Abstract excerpt

Autophagy is an evolutionarily conserved bulk-protein degradation pathway in which isolation membranes engulf the cytoplasmic constituents, and the resulting autophagosomes transport them to lysosomes. Two ubiquitin-like conjugation systems, termed Atg12 and Atg8 systems, are essential for autophagosomal formation. In addition to the pathophysiological roles of autophagy in mammals, recent mouse genetic studies...

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Identifiers

PMID: 18768753
DOI: 10.1091/mbc.e08-03-0309
PMCID: PMC2575156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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